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[18F]AlF-CD13-L1
- Development stage
- Unknown
- Lead developer
- Central South University
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Peptides
- Administration
- Intravenous
01
Overview
[18F]AlF-CD13-L1 is a fluorine-18-labeled peptide radiopharmaceutical developed by researchers at Xiangya Hospital of Central South University. It acts as a diagnostic positron emission tomography (PET) imaging tracer targeting aminopeptidase N (APN/CD13), a membrane protein that is highly overexpressed in prostate cancer, including prostate-specific membrane antigen (PSMA)-negative prostate cancer, ductal adenocarcinoma of the prostate (DAC), and intraductal carcinoma of the prostate (IDC-P). By selectively binding to CD13, [18F]AlF-CD13-L1 enables the visualization and staging of prostate cancer lesions via PET/CT imaging, addressing a critical diagnostic gap for patients with PSMA-negative disease.
- Other names
- 18F-AlF-CD13-L1[18F]F-CD13-L
02
Targets
ANPEP (Aminopeptidase N)
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